BioBond® Cell Study

The BioBond® surface technology cell study evaluated the osteoblastic differentiation of human mesenchymal stem cells (hMSC) on the ChoiceSpine 3D printed titanium alloy (Ti6Al4V) porous trabecular structure. The BioBond® surface technology utilizes additive manufacturing to create distinct and intentionally designed submicron, micro, and macro interconnected architecture to optimize surface contact, load sharing, and osseointegration potential. The study aimed to characterize the ability of these surfaces to promote bone growth while minimizing inflammatory and fibrogenic responses across a controlled range of pore dimensions and porosity. Critical indicators of implant success, including cell adhesion, proliferation, and differentiation, were monitored via protein expression.

BioBond®, the proprietary  porous trabecular surface structure, effectively mimics native bone architecture, fostering mesenchymal stem cell adhesion, proliferation, and osteoblastic differentiation.  The BioBond® osteoconductive and osteopromotive surface properties have been combined with additive manufacturing expertise to develop a complete product portfolio of state-of-the-art spinal implants.